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The Basics

What is protein synthesis?

  1) Photo: DNA replication fork.  
  

Enlarge image.Image: K.G. Murti, Visuals Unlimited, Inc.
DNA replication fork.

  
     

Protein synthesis is the transcription and translation of specific parts of DNA to form proteins.

The following is a brief overview of how a gene (a section of the DNA molecule) serves as a template for the synthesis of a protein. The process can be split into two phases. Transcription occurs first, followed by translation.

Inside the cell

 

Heredity and reproduction

 
   
 

In this section:

   

Transcription

Transcription starts with an enzyme called polymerase copying the DNA sequence to a similar molecule called messenger RNA (mRNA). It replaces T with U (Uracil), a helper base, making it clear that the mRNA is a copy. The bases (A, T, G, C) on one strand of the DNA specify the order of bases on the new strand of mRNA (A, U, G, C). The DNA stays inside the nucleus, but the mRNA travels out into the cytoplasm.

Translation

Translation is the part of protein synthesis where the ribosomes in the cytoplasm use transfer RNA (tRNA) to attach to the mRNA and translate the bases into amino acids. tRNA molecules bring the specified amino acids that the ribosome links together to make a protein.

Race the Cell
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  2) Illustration: Synthesizing proteins.  
     
 
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Image credits: 1) K.G. Murti, Visuals Unlimited, Inc.; 2) The Geee! in Genome.